- Aug 15, 2021 — Lab Research Published in American Journal of Translational Research
ShcA expression in podocytes is dispensable for glomerular development but its upregulation is associated with kidney disease has been published in the American Journal of Translational Research. Congratulations to Claire and Nina!
- Feb 22, 2021 — Jones and Lalone Lab Review Article Published in IJMS
Receptor Tyrosine Kinase Signaling and Targeting in Glioblastoma Multiforme has been published in International Journal of Molecular Sciences. Congratulations Manali and Laura, and thank you to the contributing members of the Lalonde lab!
- Jan 15, 2021 — Lab Research Published in Molecular Cancer Research
We are delighted to share our latest research published in Molecular Cancer Research and featured on the cover, Adaptor Protein ShcD/ SHC4 Interacts with Tie2 Receptor to Synergistically Promote Glioma Cell Invasion.
Martin CE, Phippen NJ, Keyvani Chahi A, Tilak M, Banerjee SL, Lu P, New LA, Williamson CR, Platt MJ, Simpson JA, Krendel M, Bisson N, Gingras AC, Jones N. (2022) Complementary Nck1/2 signaling in podocytes controls α-actinin-4-mediated actin organization, adhesion and basement membrane composition. Journal of American Society of Nephrology. In press.
Martin CE, Jones N. (2021) ShcA expression in podocytes is dispensable for glomerular development but its upregulation is associated with kidney disease. Am J Transl Res. 2021 Aug 15;13(8):9874-9882. eCollection 2021.
Tilak M, Alural B, Wismer SE, Brasher MI, New LA, Sheridan SD, Perlis RH, Coppolino MG, Lalonde J, Jones N. (2021) Adaptor Protein ShcD/SHC4 Interacts with Tie2 Receptor to Synergistically Promote Glioma Cell Invasion. Molecular Cancer Research. 2021 May;19(5):757-770. doi: 10.1158/1541-7786.MCR-20-0188.
Martin CE, New LA, Phippen NJ, Keyvani Chahi A, Mitro AE, Takano T, Pawson T, Blasutig IM, Jones N. (2020) Multivalent nephrin-Nck interactions define a threshold for clustering and tyrosine-dependent nephrin endocytosis. Journal of Cell Science. 133: jcs236877.
Robeson HN, Lau HR, New LA, Lalonde J, Armstrong JN, Jones N. (2019) Localization of phosphotyrosine adaptor protein ShcD/SHC4 in the adult rat central nervous system. BMC Neuroscience. 20: 57.
Cooper CJ, Dutta NT, Martin CE, Piscione TD, Thorner PS, Jones N. (2018) Characterization of a novel disease-associated mutation within NPHS1 and its effects on nephrin phosphorylation and signaling. PLOS One. 13(9):e0203905.
Martin CE, Jones N. (2018) Nephrin signaling in the podocyte: An updated view of signal regulation at the slit diaphragm and beyond. Frontiers in Endocrinology. 9: 302.
Martin CE, Petersen KA, Aoudjit L, Tilak M, Eremina V, Hardy WR, Quaggin SE, Takano T, Jones N. (2018) ShcA adaptor protein promotes nephrin endocytosis and is upregulated in proteinuric nephropathies. Journal of American Society of Nephrology. 29: 92-103.
Highlighted in Nature Reviews Nephrology (November 2017)
Wills MK, Lau HR, Jones N. (2017) The ShcD phosphotyrosine adaptor subverts canonical EGF receptor trafficking. Journal of Cell Science. 130: 2808-2820.
Wills MK, Keyvani Chahi A, Lau HR, Tilak M, Guild BD, New LA, Lu P, Jacquet K, Meakin SO, Bisson, N, Jones N. (2017) Signaling adaptor ShcD suppresses Erk phosphorylation distal to the Ret and Trk neurotrophic receptors. Journal of Biological Chemistry. 292: 15748-5759.
Keyvani Chahi A, Martin CE, Jones N. (2016) Nephrin Suppresses Hippo Signalling Through the Adaptor Protiens Nck and WTIP. Journal of Biological Chemistry. 291: 12799-12808.
New LA, Martin CE*, Scott RP*, Platt MJ, Keyvani Chahi A, Stringer CD, Lu P, Samborska B, Eremina V, Simpson JA, Quaggin SE, Jones N. (2016) Nephrin tyrosine phosphorylation is required for maintenance and restoration of podocyte foot process architecture. Journal of the American Society of Nephrology. 27: 2422-2435. (*denotes equal contributions)
Highlighted in Nature Reviews Nephrology (April 2016)
Clouthier DL*, Harris CN*, Harris RA*, Martin CE, Puri MC, Jones N. (2015) Requisite role for Nck adaptors in cardiovascular development, endothelial-to-mesenchymal transition and directed cell migration. Molecular and Cellular Biology, 35: 1573-1587. (*denotes equal contributions)
Selected by Editors as an Article of Significant Interest
New LA*, Martin CE*, Jones N. (2014) Advances in slit diaphragm signaling. Current Opinion in Nephrology and Hypertension, 23:420-430. (*denotes equal contributions)
Wills MK, Tong J, Tremblay SL, Moran MF, Jones N. (2014) The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF Receptor. Molecular Biology of the Cell, 25:739-752.
New LA, Keyvani Chahi A, Jones N. (2013) Direct regulation of nephrin tyrosine phosphorylation by Nck adaptor proteins. Journal of Biological Chemistry, 288:1500-1510.
Smith GS, Samborska B, Hawley SP, Klaiman J, Gillis TE, Jones N, Boggs JM, Harauz G. (2013) Nucleus-localized 21.5-kDa myelin basic protein promotes oligodendrocyte proliferation and enhances neurite outgrowth in co-culture, unlike the plasma membrane-associated 18.5-kDa isoform. Journal of Neuroscience Research, 91:349-362.
Wills MK, Jones N. (2012) Teaching an old dogma new tricks: Twenty years of Shc adaptor signalling. Biochemical Journal, 447:1-16.
Scott RP, Hawley SP, Ruston J, Du J, Brakebusch C, Jones N, Pawson T. (2012) Podocyte-specific loss of Cdc42 but not Rac1 or RhoA leads to congenital nephropathy. Journal of the American Society of Nephrology, 23:1149-1154.
Smith GS, De Avila M, Paez PM, Spreuer V, Wills MK, Jones N, Boggs JM, Harauz G. (2012) Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes. Journal of Neuroscience Research, 90:28-47.
Hawley SP, Wills MK, Rabalski AJ, Bendall AJ, Jones N. (2011) Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development. Developmental Dynamics, 240:221-231.
Hawley SP, Wills MK, Jones N. (2010) Adenovirus-mediated genetic removal of signaling molecules in cultured primary mouse embryonic fibroblasts. Journal of Visualized Experiments, 43.
JoVE Video Summary
Jones N, New LA, Fortino MA, Eremina V, Ruston J, Blasutig IM, Aoudjit L, Zou Y, Liu X, Yu G-L, Takano T, Quaggin SE, Pawson T. (2009) Nck proteins maintain the adult glomerular filtration barrier. Journal of the American Society of Nephrology, 20:1533-1543.
Highlighted in JASN (PMID 19497966)
Blasutig IM, New LA, Thanabalasuriar A, Dayarathna TK, Goudreault M, Quaggin SE, Li S S-C, Gruenheid S, Jones N, Pawson T. (2008) Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization. Molecular and Cellular Biology, 28:2035-2046.
Wills M, Jones N. (2008) The ShcD phosphotyrosine adaptor exhibits novel binding characteristics with the TrkA neurotrophin receptor. Studies by Undergraduate Researchers at Guelph, 2:29-70.
Jones N, Hardy WR, Friese MB, Jorgensen C, Smith MJ, Woody NM, Burden SJ, Pawson T. (2007) Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with Muscle-Specific Kinase (MuSK). Molecular and Cellular Biology, 27:4759-4773.
Smith MJ, Hardy WR, Murphy JM, Jones N, Pawson T (2006) Screening for PTB domain binding partners and ligand specificity using proteome-derived NPxY peptide arrays. Molecular and Cellular Biology, 26:8461-8474.
Jones N, Blasutig IM, Eremina V, Ruston JM, Bladt F, Li H, Huang H, Larose L, Li SS, Takano T, Quaggin SE, Pawson T. (2006) Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature, 440:818-823.
Cited as a “Must Read” paper in the Faculty of 1000, Medicine by Dr. David Salant
Highlighted in Cell (PMID 16630808)