Welcome to our Cell Signalling Lab
Research in our laboratory is focused on defining eukaryotic signal transduction pathways, and investigating how mutations in components of these pathways can contribute to human diseases such as kidney disease and cancer. Our research team investigates questions related to these pathways using an interdisciplinary approach which includes modern mouse genetic tools, cell culture models, high-resolution microscopy, large-scale profiling techniques and clinical specimens.
Signal transduction is a central process in multicellular organisms that allows for the exchange of informational cues between and within cells. These cues are interpreted by organized networks of protein interactions inside the cell which regulate complex biochemical events, ultimately converting them into biological responses such as growth, migration, differentiation and survival. Cells have evolved a tremendous ability to selectively activate specific downstream pathways through the formation of distinct protein complexes. Understanding the molecular basis of these interactions is a significant challenge in biology, and it is of key importance in defining how specific mutations can lead to pathological conditions such as kidney disease and cancer.
Latest Lab News
- March 28, 2025 — Lab Research Published in Molecular Oncology
ShcD Adaptor Protein Drives Invasion of Triple Negative Breast Cancer Cells by Aberrant Activation of EGFR Signaling. Molecular Oncology.…
- March 24, 2025 — Jones Lab at Banff Conference on Signaling in Normal and Cancer Cells
Jones Lab Members Nate Petersen, Erka Shata, and Hayley Smith attended this year’s conference where Hayley and Erka presented lightening talks and Nate presented a poster.
- March 24, 2025 — BIOM Undergraduate Project Presentations
Jones lab undergrad Alice Nielissen successfully presented her presentation for BIOM*4500/BIOM*4510. Great work!
- December 16, 2024 — Happy Holidays
Happy holidays from the Jones lab!
- Oct 31, 2024 — Happy Halloween
Happy Halloween from the Jones Lab! We had a fun and festive time dressing up as the Twilight Baseball scene for MCB departmental trick-or-treating.