Welcome to our Cell Signalling Lab
Research in our laboratory is focused on defining eukaryotic signal transduction pathways, and investigating how mutations in components of these pathways can contribute to human diseases such as kidney disease and cancer. Our research team investigates questions related to these pathways using an interdisciplinary approach which includes modern mouse genetic tools, cell culture models, high-resolution microscopy, large-scale profiling techniques and clinical specimens.
Signal transduction is a central process in multicellular organisms that allows for the exchange of informational cues between and within cells. These cues are interpreted by organized networks of protein interactions inside the cell which regulate complex biochemical events, ultimately converting them into biological responses such as growth, migration, differentiation and survival. Cells have evolved a tremendous ability to selectively activate specific downstream pathways through the formation of distinct protein complexes. Understanding the molecular basis of these interactions is a significant challenge in biology, and it is of key importance in defining how specific mutations can lead to pathological conditions such as kidney disease and cancer.
Latest Lab News
- Mar 9, 2023 – World Kidney Day
World Kidney Day (WKD) is celebrated internationally every second Thursday in March to raise awareness of the importance of our kidneys. This year, the theme of WKD is: Kidney Health for All – Preparing for the unexpected, supporting the vulnerable.
- Feb 11, 2023 – International Day of Women and Girls in Science
Today, the Jones lab is celebrating the UN recognized International Day of Women and Girls in Science (IDWGS) on February 11th, 2023 which calls for women’s full and equal access to and participation in science and celebrates those that are leading science innovation.
- Sept 6, 2022 — Congratulations Hannah
Congratulations to Dr. Hannah Robeson on her successful defense of her PhD thesis “Characterization of the physiological role of adaptor…
- May 15, 2022 — Jones Lab at Canadian Association of Neuroscience (CAN) Conference
Jones Lab members Begüm Alural and Cassandra Clausen presented a poster at this year’s Canadian Association of Neuroscience (CAN)…
- May 12, 2022 — Jones Lab at ICCI Conference
Jones Lab member Hayley Lau presented a talk at this year’s virtual University of Guelph Institute for Comparative Cancer…
- Aug 15, 2021 — Lab Research Published in American Journal of Translational Research
- Feb 22, 2021 — Jones and Lalone Lab Review Article Published in IJMS
- Jan 15, 2021 — Lab Research Published in Molecular Cancer Research