Welcome to our Cell Signalling Lab
Research in our laboratory is focused on defining eukaryotic signal transduction pathways, and investigating how mutations in components of these pathways can contribute to human diseases such as kidney disease and cancer. Our research team investigates questions related to these pathways using an interdisciplinary approach which includes modern mouse genetic tools, cell culture models, high-resolution microscopy, large-scale profiling techniques and clinical specimens.
Signal transduction is a central process in multicellular organisms that allows for the exchange of informational cues between and within cells. These cues are interpreted by organized networks of protein interactions inside the cell which regulate complex biochemical events, ultimately converting them into biological responses such as growth, migration, differentiation and survival. Cells have evolved a tremendous ability to selectively activate specific downstream pathways through the formation of distinct protein complexes. Understanding the molecular basis of these interactions is a significant challenge in biology, and it is of key importance in defining how specific mutations can lead to pathological conditions such as kidney disease and cancer.
Latest Lab News
- July 21, 2023 — Lab Research Published in Journal of Mammary Gland Biology and Neoplasia
Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development. J Mammary Gland Biol Neoplasia. 2023 Jul…
- July 21, 2023 — Jones Lab Receives CIHR Grant
The Jones Lab is thrilled to announce our success in obtaining a grant from the Canadian Institutes of Health Research (CIHR) to support our kidney disease research!
- June 25, 2023 — Congratulations Begüm
Postdoctoral fellow Dr. Begüm Alural is this year’s recipient of the College of Biological Science (CBS) Mentorship Award for Post-Doctoral Fellows…
- Jun 14, 2023 — Jones Lab at Guelph Cardiovascular Research Day
Outstanding work from Jones Lab MSc student Alyssa Campbell who presented about her research at the annual Cardiovascular Research…
- June 13, 2023 — Congratulations Jones Lab Graduates
Congratulations to Jones Lab members Alice, Emma, and Hyeyun for completing their undergraduate degrees in Molecular Biology & Genetics, Biological Science, and Biomedical Sciences!