Welcome to our Cell Signalling Lab
Research in our laboratory is focused on defining eukaryotic signal transduction pathways, and investigating how mutations in components of these pathways can contribute to human diseases such as kidney disease and cancer. Our research team investigates questions related to these pathways using an interdisciplinary approach which includes modern mouse genetic tools, cell culture models, high-resolution microscopy, large-scale profiling techniques and clinical specimens.
Signal transduction is a central process in multicellular organisms that allows for the exchange of informational cues between and within cells. These cues are interpreted by organized networks of protein interactions inside the cell which regulate complex biochemical events, ultimately converting them into biological responses such as growth, migration, differentiation and survival. Cells have evolved a tremendous ability to selectively activate specific downstream pathways through the formation of distinct protein complexes. Understanding the molecular basis of these interactions is a significant challenge in biology, and it is of key importance in defining how specific mutations can lead to pathological conditions such as kidney disease and cancer.
Latest Lab News
- April 29, 2022 — Jones Lab at CBS Graduate Student Symposium
Lab Member Hannah Robeson won a “Best Poster” award ($75) and Lab Member Casey Williamson received a “Best Poster” Honourable Mention at this year’s Graduate Student Symposium! Congratulations!
- December 20, 2021 — Happy Holidays
Happy holidays from the Jones Lab. Here’s to a great 2022!
- Dec. 5, 2021 — Jones Lab at Molecules & Mechanisms Mediating Kidney Health & Disease Conference
Jones Lab members attended (remotely) the M3K Molecules & Mechanisms Mediating Kidney Health & Disease conference, where lab alum Dr. Claire Martin won an award for her poster about Jones Lab research.
- Oct 28, 2021 — Pumpkin carving contest entry
The Jones Lab 2021 entry designed by the masterful Alyssa Campbell!
- Oct 6, 2021 — Congratulations Adam
Congratulations to Dr. Adam Golding on his successful defense of his PhD thesis “Investigation of Nck1 and Nck2 in mammary gland development and breast cancer“.
