Welcome to our Cell Signalling Lab
Research in our laboratory is focused on defining eukaryotic signal transduction pathways, and investigating how mutations in components of these pathways can contribute to human diseases such as kidney disease and cancer. Our research team investigates questions related to these pathways using an interdisciplinary approach which includes modern mouse genetic tools, cell culture models, high-resolution microscopy, large-scale profiling techniques and clinical specimens.
Signal transduction is a central process in multicellular organisms that allows for the exchange of informational cues between and within cells. These cues are interpreted by organized networks of protein interactions inside the cell which regulate complex biochemical events, ultimately converting them into biological responses such as growth, migration, differentiation and survival. Cells have evolved a tremendous ability to selectively activate specific downstream pathways through the formation of distinct protein complexes. Understanding the molecular basis of these interactions is a significant challenge in biology, and it is of key importance in defining how specific mutations can lead to pathological conditions such as kidney disease and cancer.
Latest Lab News
- Feb 11, 2024 – International Day of Women and Girls in Science
Today, the Jones lab is celebrating the UN recognized International Day of Women and Girls in Science (IDWGS) on February 11th, 2024 which calls for women’s full and equal access to and participation in science and celebrates those that are leading science innovation.
- Aug 24, 2023 — Congratulations Alyssa!
Congratulations to Alyssa Campbell on her successful Masters defense on Investigating Nectin-2 in Kidney Podocytes!
- December 20, 2023 — Happy Holidays
Happy holidays from the Jones lab!
- Oct 31, 2023 — Pumpkin carving contest entry
The Jones Lab 2023 pumpkin carving was a group effort valiantly led by PhD candidate Casey Williamson! This artwork is named “Spooky Transcriptomics” – inspired by a cytokine storm.
- Aug 10, 2023 — Jones Lab at Ontario Cell Biology Symposium
Jones Lab attended and help hosted the Ontario Cell Biology Symposium at the University of Guelph this year.
- July 21, 2023 — Lab Research Published in Journal of Mammary Gland Biology and Neoplasia
- Sept 30, 2022 — Lab Research Published in Canadian Journal of Kidney Health and Disease
- Aug 14, 2022 — Lab Research Published in JASN