Welcome to our Cell Signalling Lab
Research in our laboratory is focused on defining eukaryotic signal transduction pathways, and investigating how mutations in components of these pathways can contribute to human diseases such as kidney disease and cancer. Our research team investigates questions related to these pathways using an interdisciplinary approach which includes modern mouse genetic tools, cell culture models, high-resolution microscopy, large-scale profiling techniques and clinical specimens.
Signal transduction is a central process in multicellular organisms that allows for the exchange of informational cues between and within cells. These cues are interpreted by organized networks of protein interactions inside the cell which regulate complex biochemical events, ultimately converting them into biological responses such as growth, migration, differentiation and survival. Cells have evolved a tremendous ability to selectively activate specific downstream pathways through the formation of distinct protein complexes. Understanding the molecular basis of these interactions is a significant challenge in biology, and it is of key importance in defining how specific mutations can lead to pathological conditions such as kidney disease and cancer.
Latest Lab News
- Sept 18, 2025 — Kidney “Bake” Sale Fundraiser
Our continuously evolving annual kidney “bake sale” fundraiser to support the Kidney Foundation of Canada was a major success this year!
- Sept 16, 2025 — Congratulations Alice
Congratulations to Alice for passing her qualifying exam! The Jones lab has just gained another PhD candidate.
- Aug 7th, 2025 — Jones Lab at Ontario Cell Biology Symposium
Jones Lab attended the Ontario Cell Biology Symposium at Brock University in St. Catherines this year. We also stopped by Port Dalhousie on the way.
- July 14, 2025 — Alice Awarded Vanier Scholarship
Jones Lab Ph.D. student Alice Wang has been selected as an NSERC Vanier Scholar in the last cohort of the prestigious Vanier Canadian Graduate Scholarship.
- July 10, 2025 — MCB Departmental Barbeque
The Jones Lab attended the 2025 MCB Departmental Barbeque. Congratulations to all the honourees this year, including our own Peihua Lu who has been devoted to MCB for 30 years now – Wow!